Rooted in Deep Science

Remepy’s combination apps are designed for hybrid drug experiences, each containing a unique digital treatment protocol. The proprietary adaptive treatment protocols include digitized, standardized, innovative and evidence-based interventions, designed to enhance neuro plasticity, improve motor control, balance the immune system, and drive behavioral changes. We address primary disease end-points as well as side-effects and disease comorbidities

Digital Mechanisms of Action

Our interventions trigger unique mechanisms of action demonstrated in our clinical trials using fMRI imaging, blood and saliva samples, and standardized questionnaires. We directly impact brain activity and structure and have a downstream effect on the neuro-endocrine and neuro-immunological systems.
Mechanisms of action amplify each other’s effect, creating a larger impact when activated together.

Enhance brain plasticity

Contrary to common belief, our brain maintains its plasticity in adulthood. Enriched multisensory environments can optimize neural structure and function, improve memory, motor, emotional and cognitive functioning.

Reduce systemic inflammation

Chronic stress causes neuroendocrine imbalance, activating the Sympathetic Nervous System and Hypothalamic-Pituitary-Adrenal axis, negatively impacting the immune system. This has a reciprocal influence on the brain - with systemic neuroinflammation accelerating brain neurodegeneration. Psychological and cognitive interventions target these mechanisms by positively impacting immune system function.

Trigger the reward system

Activation of the brain reward system has robust effects both on brain plasticity and on the immune system. A carefully designed interactive environment for cognitive training harnesses this ability by triggering activation in the brain reward system, in tandem with multi-modal beneficial behaviors reinforces the brain circuits involved in this behavior and sets off a beneficial cascade of neuro-immune effects.

Improve motor control

For diseases with movement disorders like Parkinson’s Disease, targeted physiotherapy interventions are added to the treatment protocol. These interventions are aimed at strengthening muscle memory to help with everyday tasks. For example: speech therapy, gross and fine motor skills, walking, and occupational therapy.

Rebalance emotion & cognitive networks

Evidence-based digital interventions addressing psychological symptoms, such as stress, anxiety, depression, and sleep are part of the treatment protocol. Interventions such as attention training, psychoeducation, thought and interpretation modification, and emotion regulation.

Non-invasive visual, auditory and tactile stimulation

We develop evidence based non-invasive cognitive, psychological, and behavioral interventions that follow principles of sensory integration, sensory substitution and sensory masking. Digital interventions are designed to trigger multiple mechanisms of action at play, enabling the synergistic effect. They aim to enhance (and sometimes prolong) the effect of the drug and address symptoms.

Spatial navigation

Motor control

Sensorimotor control

Memory control

Emotion regulation

Vestibular control

We target drugs for diseases where meaningful changes to brain connectivity, changes to the immune system, and behavioral changes are synergistic with drug effects.
Current focus areas include: