The Science of
‍Hybrid Drugs^TM

Remepy's Hybrid Drugs, each combine traditional medication together with personalized app-delivered digital treatment protocols.

The proprietary adaptive treatment protocols include digitized, innovative, and evidence-based interventions, designed to enhance neuroplasticity, improve motor control, balance the immune system, and drive behavioral changes. We address primary disease endpoints as well as side effects and disease-associated conditions.

Rooted in Deep Science: How It Works

Remepy’s research-backed interventions trigger unique mechanisms of action demonstrated in our clinical trials using fMRI imaging, blood and saliva samples, and standardized questionnaires.

We directly impact brain activity and structure and have a downstream effect on the neuro-endocrine and neuro-immunological systems. These mechanisms of action amplify each other's effect, creating a larger impact when activated together.

Digital Mechanisms of Action

The key mechanisms below demonstrate a synergistic effect that improves outcomes beyond medication alone. These mechanisms are intelligently combined and implemented for patients in a personalized, app-delivered experience:

Reduce systemic inflammation

Chronic stress causes neuroendocrine imbalance, activating the Sympathetic Nervous System and Hypothalamic-Pituitary-Adrenal axis, negatively impacting the immune system. This has a reciprocal influence on the brain - with systemic neuroinflammation accelerating brain neurodegeneration. Psychological and cognitive interventions target these mechanisms by positively impacting immune system function.

Enhance brain
plasticity

Contrary to common belief, our brain maintains its plasticity in adulthood. Enriched multisensory environments can optimize neural structure and function, improve memory, motor, emotional, and cognitive functioning.

Trigger the
reward system

Activation of the brain reward system has robust effects both on brain plasticity and on the immune system. A carefully designed interactive environment for cognitive training harnesses this ability by triggering activation in the brain reward system; in tandem with multi-modal beneficial behaviors, this reinforces the brain circuits involved in this behavior and sets off a beneficial cascade of neuro-immune effects.

Improve motor
control

For diseases with movement disorders like Parkinson's Disease, targeted physiotherapy interventions are added to the treatment protocol. These interventions are aimed at strengthening muscle memory to help with everyday tasks. For example: speech therapy, gross and fine motor skills, walking, and occupational therapy.

Rebalance emotion & cognitive networks

Evidence-based digital interventions addressing psychological symptoms, such as stress, anxiety, depression, and sleep are part of the treatment protocol. Interventions include attention training, psychoeducation, thought and interpretation modification, and emotion regulation.

Non-invasive Stimulation Visual, Auditory & Tactile

We develop evidence-based non-invasive cognitive, psychological, and behavioral interventions that follow principles of sensory integration, sensory substitution, and sensory masking. Digital interventions are designed to trigger multiple mechanisms of action at play, enabling the synergistic effect. They aim to enhance (and sometimes prolong) the effect of the drug and address symptoms.

These interventions are designed to engage specific neurological domains.

Spatial Navigation

Motor Control

Sensorimotor Control

Memory Control

Emotion Regulation

Vestibular Control

Validated by Biology

When developing our Hybrid Drugs, we don’t rely on self-reported feelings alone. Our clinical trials measure hard biological endpoints to prove the hybrid effect, including:

fMRI Imaging
Visualizing changes in brain connectivity and structure.
Biomarkers
Analyzing blood and saliva for markers of inflammation (Cortisol, Cytokines).
Standardized Clinical Scales
Using the gold-standard metrics for each disease state (e.g., MDS-UPDRS for Parkinson's).